5-Bromo-[1,3]thiazolo[5,4-b]pyridin-2-amine → 2-(2,6-Dichlorophenyl)-1H-indole-6-carboxylic acid (5-bromothiazolo[5,4-b]pyridin-2-yl)-amide

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Reaction Steps

The title compound was prepared from 2-(2,6-dichlorophenyl)-1H-indole-6-carboxylic acid and 5-bromothiazolo[5,4-b]pyridin-2-ylamine (WO 2007041365) analogous to Example 3-11. 1H NMR (DMSO-d6, 400 MHz): δ 13.08 (s, broad, 1H), 12.01 (s, broad, 1H) 8.33 (s, 1H), 8.11 (d, J=8.5 Hz, 1H), 7.86 (dd, J=8.5, 1.5 Hz, 1H), 7.71 (m, 4H), 7.56 (m, 1H), 6.65 (d, J=1.3 Hz, 1H). MS (m/z) 518.9 (M+1), Retention time=1.58 min (Method 10). High Res. MS: theory 516.9292; measured 516.9277.

Provenance & Evidence