Sodium Hydroxide → 4-Amino-2,6-dimethylbenzaldehyde

HRID 1514977Notes

Reaction equation

HRID 1514977 reaction equation
FC(F)(F)C([NH:5][C:6]1[CH:11]=[C:10]([CH3:12])[C:9]([CH:13]=[O:14])=[C:8]([CH3:15])[CH:7]=1)=O.[OH-].[Na+]>CO>[NH2:5][C:6]1[CH:7]=[C:8]([CH3:15])[C:9]([CH:13]=[O:14])=[C:10]([CH3:12])[CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 866328212,2,2-trifluoro-N-(4-formyl-3,5-dimethylphenyl)acetamide

Product 1

HCID 123812354-Amino-2,6-dimethylbenzaldehyde

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2,2,2-trifluoro-N-(4-formyl-3,5-dimethylphenyl)-acetamide (1.0 g) in MeOH (20 mL) was added 1N NaOH (16.3 mL). After 4 hrs at room temperature, the suspension was filtered and washed with water. The solid was dried under reduced pressure to give 4-amino-2,6-dimethylbenzaldehyde as a light yellow solid. MS (ESI)m/z 150 (M+H).

Workup

  1. filtrationthe suspension was filtered
  2. washwashed with water
  3. customThe solid was dried under reduced pressure

Sources & evidence

ORD record
ord-eb7b9edbaa804db0a40bbe7e4a888f42
Source dataset
uspto-grants-2012_07
Patent number
US08222248B2

Reaction notes

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