Hydrochloric Acid → HCID 66965217, compound

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Reaction Steps

To a solution of {3-chloro-4-[6-(3,4-dimethylphenylcarbamoyl)-1H-benzoimidazol-2-yl]-phenoxy}-acetic acid methyl ester (100 mg, 0.21 mmol) in MeOH (3 mL) was added 1N NaOH (3 mL) and the solution was stirred at ambient temperature for 3 h. The solution was carefully acidified to pH 3-4 with 1N HCl and the suspension was filtered, washed with water, and the white solid was dried in vacuum oven to give the title compound. 1H NMR (Methanol-d4, 400 MHz): δ 8.26 (s, 1H), 7.92 (dd, 1H), 7.84 (d, 2H), 7.74 (d, 1H), 7.48 (dd, 1H), 7.44 (dd, 1H), 7.23 (dd, 1H), 7.14 (m, 2H), 4.80 (s, 2H), 2.30 (s, 3H), 2.27 (s, 3H). MS (m/z) 450.2 (M+1) Retention time: 1.19 min (Method 10).

Provenance & Evidence