HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide → HCID 66965236, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Reactant | 1-Isoquinolinamine | HCID 73742 | — |
| Reactant | Benzoic acid, 4-amino-3-nitro- | HCID 74115 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 66965236 | HCID 66965236 | — |
Reaction Steps
To a solution of 4-amino-3-nitrobenzoic acid (546 mg), EDCI (576 mg) and HOBt (405 mg) in DMF (7 mL) was added isoquinolin-1-ylamine (432 mg) and the mixture was stirred at ambient temperature for 18 h. Water was added and the orange precipitate was filtered to give 4-amino-N-isoquinolin-1-yl-3-nitrobenzamide.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222248B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-138877a2136c417293fe649672d545ca |
| Source note | uspto-grants-2012_07 |