3,4-diamino-N-quinolin-2-yl-benzamide → {3,5-Dichloro-4-[6-(quinolin-2-ylcarbamoyl)-1H-benzoimidazol-2-yl]-phenoxymethyl}-phosphonic acid diethylester
Reaktionsgleichung
[NH2:1][C:2]1[CH:3]=[C:4]([CH:18]=[CH:19][C:20]=1[NH2:21])[C:5]([NH:7][C:8]1[CH:17]=[CH:16][C:15]2[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=2)[N:9]=1)=[O:6].[CH2:22]([O:24][P:25]([CH2:30][O:31][C:32]1[CH:37]=[C:36]([Cl:38])[C:35]([CH:39]=O)=[C:34]([Cl:41])[CH:33]=1)(=[O:29])[O:26][CH2:27][CH3:28])[CH3:23]>>[CH2:22]([O:24][P:25]([CH2:30][O:31][C:32]1[CH:37]=[C:36]([Cl:38])[C:35]([C:39]2[NH:1][C:2]3[CH:3]=[C:4]([C:5](=[O:6])[NH:7][C:8]4[CH:17]=[CH:16][C:15]5[C:10](=[CH:11][CH:12]=[CH:13][CH:14]=5)[N:9]=4)[CH:18]=[CH:19][C:20]=3[N:21]=2)=[C:34]([Cl:41])[CH:33]=1)(=[O:29])[O:26][CH2:27][CH3:28])[CH3:23]Komponenten
3
Versuchsvorschrift
The title compound was prepared from 3,4-diamino-N-quinolin-2-yl-benzamide (from Example 6-17) and (3,5-dichloro-4-formylphenoxymethyl)-phosphonic acid diethyl ester analogous to Example 6-17. 1H NMR (Methanol-d4, 400 MHz): δ 8.77 (d, 1H), 8.54 (d, 1H), 8.17 (t, 1H), 8.16 (t, 1H), 8.12 (d, 1H), 8.07 (d, 1H), 7.99 (m, 1H), 7.86 (d, 1H), 7.77 (m, 1H), 7.38 (s, 2H), 4.62 (d, 2H), 4.30 (m, 4H), 1.42 (t, 6H). MS (m/z) 599.5 (M+1); Retention time: 1.40 min (Method 10).
Quellen und Nachweise
- ORD-Eintrag
- ord-be19f02c335a4dbcb53ac6618bae5e4a
- Quelldatensatz
- uspto-grants-2012_07
- Patentnummer
- US08222248B2
Notizen zur Reaktion
Wird geladen…