HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-amino-3-nitro-N-(6-trifluoromethylpyridin-3-yl)-benzamide → 3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-amino-3-nitro-N-(6-trifluoromethylpyridin-3-yl)-benzamide | HCID 66966225 | — |
| Catalyst | Platinum | HCID 23939 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide | HCID 66965681 | — |
Reaction Steps
A suspension of 4-amino-3-nitro-N-(6-trifluoromethylpyridin-3-yl)-benzamide (500 mg, 1.53 mmol) in THF (20 mL) was hydrogenated at one atm over Pt/C (50 mg) for 3 hours. The catalyst was filtered through Celite and washed with THF. The solvent was removed under reduced pressure to give 3,4-diamino-N-(6-trifluoromethylpyridin-3-yl)-benzamide as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222248B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-4056b359be5f40d7994d8945c7409051 |
| Source note | uspto-grants-2012_07 |