Ethyl Acetate → HCID 66966212, compound

Participants

Reaction Steps

To a solution of 2-(2,6-dimethylphenyl)-3H-benzoimidazole-5-carboxylic acid methyl ester (930 mg) (Example 1-255, step 1) in THF (10 mL) was added 16.6 mL of a 1M solution of LiAlH4 in ether dropwise. The mixture was stirred at ambient temperature for 18 h then approximately 4 mL of saturated sodium sulfate solution was added dropwide. Ethyl acetate was added to the mixture and the solvent decanted from any insoluble material. The organic solution was dried over sodium sulfate and the solvent was removed under reduced pressure to give [2-(2,6-dimethylphenyl)-3H-benzoimidazol-5-yl]-methanol as a foam.

Provenance & Evidence