3,4-Dimethylaniline → HCID 66965746, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(2,6-dimethylphenyl)-6-(2,2,2-trifluoroacetyl)-benzoimidazole-1-carboxylic acid tert-butyl ester (617 mg) and 3,4-dimethylaniline (118 mg) in toluene (10 mL) was added 4 Å molecular sieves and pTos-OH (50 mg) then the mixture was stirred at 120° C. for 18 h. The sieves were filtered and the filtrate evaporated under reduced pressure to give 1-[2-(2,6-dimethylphenyl)-3H-benzoimidazol-5-yl]-2,2,2-trifluoro-ethanone as an oil.

Provenance & Evidence