Triphenylphosphine → Ethyl 3-ethoxy-3-[4-({4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methoxy)phenyl]propionate

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-ethoxy-3-(4-hydroxyphenyl)propionate (108 mg, 0.453 mmol) produced in Example 1 (1C) and {4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}methanol (124 mg, 0.453 mmol) were dissolved in tetrahydrofuran (10 mL), and triphenylphosphine (178 mg, 0.680 mmol) and a 40% diethyl azodicarboxylate toluene solution (309 μL, 0.680 mmol) were added thereto at room temperature, and then, the resulting mixture was stirred under a nitrogen atmosphere at 50° C. for 4 hours.

Provenance & Evidence