Potassium Iodide → HCID 67058166, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-ethoxy-3-(4-hydroxyphenyl)propionate (100 mg, 0.420 mmol) produced in Example 1 (1C) was dissolved in dimethylformamide (2.0 mL), and 3-phenoxybenzyl chloride (116 μL, 0.63 mmol), potassium carbonate (174 mg, 1.26 mmol), and potassium iodide (catalytic amount, about 5 mg) were sequentially added thereto at room temperature, and then, the resulting mixture was stirred under a nitrogen atmosphere at 40° C. for 4 hours. To the reaction solution, a saturated aqueous solution of ammonium chloride was added, and the organic matter was extracted with ethyl acetate. The organic layer was washed with water and a saturated sodium chloride solution, then dried over anhydrous sodium sulfate and filtered. Then, the solvent was distilled off under reduced pressure, whereby a crude product was obtained. This crude product was purified by silica gel column chromatography (hexane:ethyl acetate=100:0 to 80:20 (v/v)), whereby the objective title compound was obtained (165 mg, yield: 93%).

Provenance & Evidence