Cesium carbonate → HCID 59439213, compound

HRID 1515123Notes

Reaction equation

HRID 1515123 reaction equation
[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11]([F:14])[CH:12]=3)[C:7](=[O:16])[C:6]([C:17]([OH:19])=[O:18])=[CH:5]2)[CH2:3][CH2:2]1.Cl.Cl[CH2:22][CH2:23][N:24]([CH3:26])[CH3:25].C(=O)([O-])[O-].[Cs+].[Cs+]>>[CH:1]1([N:4]2[C:13]3[C:8](=[CH:9][C:10]([F:15])=[C:11]([F:14])[CH:12]=3)[C:7](=[O:16])[C:6]([C:17]([O:19][CH2:22][CH2:23][N:24]([CH3:26])[CH3:25])=[O:18])=[CH:5]2)[CH2:2][CH2:3]1

Participants

4

Reactant 3

HCID 10796Cesium carbonateHCID 52104221-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acidHCID 11636816N,N-Dimethylaminoethyl chloride hydrochloride

Product 1

HCID 59439213HCID 59439213, compoundYield 74.2%

Procedure

1-Cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (300 mg, 1.13 mmol), 2-chloro-N,N-dimethylethylamine hydrochloride (196 mg, 1.36 mmol), and cesium carbonate (1.11 g, 3.39 mmol) were reacted in accordance with the method of First Step of Example 3 to obtain 282 mg of the heading compound as a colorless powdery crystal (yield 74%).

Sources & evidence

ORD record
ord-cf44496fb592441b8d20d8967b68b2c9
Source dataset
uspto-grants-2012_07
Patent number
US08222407B2

Reaction notes

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