Sodium Chloride → 5-(4-Methylpiperazin-1-yl)-2-nitroaniline

Participants

Reaction Conditions

Reaction Steps

To a 4-dram vial was added 5-Chloro-2-nitroaniline (0.5 g, 2.90 mmol, 1 equiv.), NaOH (0.229 g, 5.71 mmol, 1.98 equiv.), 4′M NaCl (0.82 mL, aq.), and 1-methylpiperazine (0.643 g, 0.71 mL, 5.79 mmol, 2 equiv.). The mixture was heated on a hot plate to 105° C. for 22 h. De-ionized H2O (6 mL) was added to the mixture, which was cooled to room temperature, and the precipitate collected on a Buchner funnel. The precipitate was then washed with de-ionized H2O (5 mL) and heptane (5 mL). After drying in a vacuum oven (80° C., 30 in. Hg) overnight, the product (0.624 g, 91.1%) was collected. According to HPLC analysis, the sample had a purity of 99.6%.

Provenance & Evidence