反应详情

A 2 mol/L aqueous sodium hydroxide solution (250 mL) was added to a methanol (1 L) solution of methyl 2-(4-bromophenoxymethyl)-benzoate (139 g, 432 mmol), and the mixture was stirred overnight while heating under reflux. Methanol was distilled off under a reduced pressure, and a 6 mol/L hydrochloric acid was added to the residue obtained to precipitate the crystals, and the precipitated crystals were collected by filtration, and sufficiently washed with water. The crystals were dried over phosphorus pentoxide at 50° C., to give 112 g (84%) of the captioned compound.

1. temperaturewhile heating
2. temperatureunder reflux
3. distillationMethanol was distilled off under a reduced pressure
4. additiona 6 mol/L hydrochloric acid was added to the residue
5. customobtained
6. customto precipitate the crystals
7. filtrationthe precipitated crystals were collected by filtration
8. washsufficiently washed with water
9. dry with materialThe crystals were dried over phosphorus pentoxide at 50° C.