反应详情

7-Nitro-1H-indole-2-carboxylic acid (2-chloro-ethyl)-amide (267 mg, 1 mmol) prepared in Step B was dissolved in dichloroethane (10 mL) and toluene (10 mL), and Lawesson's Reagent (1.29 g, 3.2 mmol) was added thereto. The mixture was refluxed for 4 h, and distilled under reduced pressure. Water was added thereto, and the reaction mixture was extracted with ethyl acetate, dried over anhydrous magnesium sulfate, and filtered. The filtrate was distilled under reduced pressure, and the concentrate was purified by column chromatography to give the title compound as a product of the cyclization reaction (148 mg, Yield 60%).

1. temperatureThe mixture was refluxed for 4 h
2. distillationdistilled under reduced pressure
3. additionWater was added
4. extractionthe reaction mixture was extracted with ethyl acetate
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationfiltered
7. distillationThe filtrate was distilled under reduced pressure
8. customthe concentrate was purified by column chromatography