Methyl 3-chloro-2-oxopropanoate → 2-(7-Nitro-1H-indol-2-yl)-thiazole-4-carboxylic acid methyl ester

HRID 1515271Notes

Reaction equation

HRID 1515271 reaction equation
[CH3:1][O:2][C:3](=[O:8])[C:4](=O)[CH2:5]Cl.[N+:9]([C:12]1[CH:13]=[CH:14][CH:15]=[C:16]2[C:20]=1[NH:19][C:18]([C:21](=[S:23])[NH2:22])=[CH:17]2)([O-:11])=[O:10]>>[CH3:1][O:2][C:3]([C:4]1[N:22]=[C:21]([C:18]2[NH:19][C:20]3[C:16]([CH:17]=2)=[CH:15][CH:14]=[CH:13][C:12]=3[N+:9]([O-:11])=[O:10])[S:23][CH:5]=1)=[O:8]

Participants

3

Reactant 2

HCID 12530121Methyl 3-chloro-2-oxopropanoateHCID 579018667-nitro-1H-indole-2-carbothioamide

Product 1

HCID 1363372002-(7-Nitro-1H-indol-2-yl)-thiazole-4-carboxylic acid methyl ester

Procedure

3-Chloro-2-oxo-propionic acid methyl ester and 7-nitro-1H-indole-2-carbothioic acid amide prepared in Step A of Preparation 110 were reacted according to the same procedure as Preparation 110 to give the title compound.

Workup

  1. customwere reacted
  2. customaccording to the same procedure as Preparation 110

Sources & evidence

ORD record
ord-2a90e0c8ac794a579ccb47c6ddd5ae83
Source dataset
uspto-grants-2012_07
Patent number
US08222414B2

Reaction notes

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