Methyl L-prolinate → 2-{2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethyl}-pyrrolidine-2-carboxylic acid methyl ester

Participants

Role	Name	HCID	Charge
Reactant	Methyl L-prolinate	HCID 853477	—
Reactant	2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethanol	HCID 25196146	—
Product	2-{2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethyl}-pyrrolidine-2-carboxylic acid methyl ester	HCID 68485344	—

Reaction Steps

2-[(R)-2-(5-chloro-7-cyclopentylamino-1H-indol-2-yl)-4,5-dihydro-thiazol-4-yl]-ethanol prepared in Example 5 and (S)-pyrrolidin-2-yl-carboxylic acid methyl ester were reacted according to the same procedure as Example 156 to give the title compound.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08222414B2
Source dataset	uspto-grants-2012_07
ORD ID	ord-618d13c664b8403bb167d04409e95b55
Source note	uspto-grants-2012_07