Hydrochloric Acid → HCID 59428625, compound

Participants

Reaction Steps

A 25-mL round-bottomed flask equipped with magnetic stirrer is charged with Compound 1c (0.580 g, 1.49 mmol), THF (10 mL) and 2N hydrochloric acid (2.0 mL). The reaction is then stirred at room temperature for 1 h. After such time, the reaction is partitioned between ethyl acetate (15 mL) and water (15 mL). The aqueous layer is separated and washed with ethyl acetate (2×25 mL). After basifying to pH 9 with solid potassium carbonate in order to liberate the free base of Compound 1d, the aqueous layer is extracted with ethyl acetate (2×25 mL). The extracts are then combined and dried over sodium sulfate. The sodium sulfate is removed by filtration and the filtrate concentrated under reduced pressure. The resulting residue is then purified by column chromatography to afford Compound 1d as a white solid.

Provenance & Evidence