反应详情

Compound 3d (75 mg, 0.334 mmol) is dissolved in dimethylformamide/dichloromethane (1:4, 5.0 mL) and 2-isocyanato-1-methoxy-4-trifluoromethyl-benzene (1.0 equiv., 73 mg, 0.334 mmol) is added at room temperature and allowed to react for 16 hours under nitrogen atmosphere. All solvent is then removed on a rotary evaporator and toluene (3×25 mL) is added and stripped off to remove residual dimethylformamide. The crude solid is then triturated using ethyl ether, and the resulting solid is then filtered and dried yielding title compound as a white solid.

1. customto react for 16 hours under nitrogen atmosphere
2. customAll solvent is then removed on a rotary evaporator and toluene (3×25 mL)
3. additionis added
4. customto remove residual dimethylformamide
5. customThe crude solid is then triturated
6. filtrationthe resulting solid is then filtered
7. customdried