3-Chloro-2-hydrazinylpyridine → methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

HRID 1515370노트

반응식

HRID 1515370 반응식
CC1(C)O/[C:5](=[CH:7]/[C:8](=[O:13])[C:9]([O:11][CH3:12])=[O:10])/[CH2:4][O:3]1.[NH:15]([C:17]1[C:22]([Cl:23])=[CH:21][CH:20]=[CH:19][N:18]=1)[NH2:16]>C(O)(C)C>[Cl:23][C:22]1[C:17]([N:15]2[C:8]([OH:13])([C:9]([O:11][CH3:12])=[O:10])[CH2:7][C:5]([CH2:4][OH:3])=[N:16]2)=[N:18][CH:19]=[CH:20][CH:21]=1

참가 물질

4

반응물 2

HCID 5561003-Chloro-2-hydrazinylpyridineHCID 54577624methyl (3E)-3-(2,2-dimethyl-1,3-dioxolan-4-ylidene)-2-oxopropanoate

생성물 1

HCID 54577408methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

The mixture of methyl (3E)-3-(2,2-dimethyl-1,3-dioxolan-4-ylidene)-2-oxopropanoate (20 g, 0.1 mol) and 2-hydrazino-3-chloropyridine (21.4 g, 0.15 mol) in 150 ml of isopropanol was stirred for 8 hours at RT. The precipitate was filtered off and washed with hexane. This gave 27.6 g (85%) of the product as a pale yellow solid with a m.p. of 113-115° C.

후처리

  1. filtrationThe precipitate was filtered off
  2. washwashed with hexane

출처 및 근거

ORD 기록
ord-16687accc22a4b85b96398aac0448ee5
출처 데이터셋
uspto-grants-2012_07
특허 번호
US08222435B2

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