HRID1515370

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID556100

3-Chloro-2-hydrazinylpyridine

C5H6ClN3

$结构：COC(=O)C(=O)/C=C1\COC(C)(C)O1$

HCID54577624

未命名化合物

PRODUCTS

生成物

HCID54577408

Methyl 1-(3-chloropyridin-2-yl)-5-hydroxy-3-(hydroxymethyl)-4,5-dihydro-1H-pyrazole-5-carboxylate

C11H12ClN3O4

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

The mixture of methyl (3E)-3-(2,2-dimethyl-1,3-dioxolan-4-ylidene)-2-oxopropanoate (20 g, 0.1 mol) and 2-hydrazino-3-chloropyridine (21.4 g, 0.15 mol) in 150 ml of isopropanol was stirred for 8 hours at RT. The precipitate was filtered off and washed with hexane. This gave 27.6 g (85%) of the product as a pale yellow solid with a m.p. of 113-115° C.

WORKUP

后处理

filtrationThe precipitate was filtered off
washwashed with hexane