反应详情

A solution of ammonia in methanol (40 mL, 2 M) is added to the crude 3-chlorosulfonyl-4-methyl-benzoic acid and the solution stirred at room temperature for 16 hours. The volume is reduced by 50% by heating under reduced pressure, the solution is filtered to remove the precipitate and the precipitate washed with additional methanol. The sulphonamide precipitate is used directly in the next step.

1. temperatureby heating under reduced pressure
2. filtrationthe solution is filtered
3. customto remove the precipitate
4. washthe precipitate washed with additional methanol