Ammonia → 4-Methyl-3-sulfamoylbenzoic acid

HRID 1515426Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1515426
[NH3:1].Cl[S:3]([C:6]1[CH:7]=[C:8]([CH:12]=[CH:13][C:14]=1[CH3:15])[C:9]([OH:11])=[O:10])(=[O:5])=[O:4]>CO>[CH3:15][C:14]1[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][C:6]=1[S:3](=[O:5])(=[O:4])[NH2:1]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 2418593-(Chlorosulfonyl)-4-methylbenzoic acid

Produkt 1

HCID 2395854-Methyl-3-sulfamoylbenzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of ammonia in methanol (40 mL, 2 M) is added to the crude 3-chlorosulfonyl-4-methyl-benzoic acid and the solution stirred at room temperature for 16 hours. The volume is reduced by 50% by heating under reduced pressure, the solution is filtered to remove the precipitate and the precipitate washed with additional methanol. The sulphonamide precipitate is used directly in the next step.

Aufarbeitung

  1. temperatureby heating under reduced pressure
  2. filtrationthe solution is filtered
  3. customto remove the precipitate
  4. washthe precipitate washed with additional methanol

Quellen und Nachweise

ORD-Eintrag
ord-d17d39469ae3447e949b2df49d94d55e
Quelldatensatz
uspto-grants-2012_07
Patentnummer
US08222424B2

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