3-Methoxy-4-(methoxycarbonyl)benzeneboronic acid → 3'-Chloro-4'-[2-(1-ethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-3-methoxy-biphenyl-4-carboxylic acid methyl ester

HRID 151550Notes

Reaction equation

HRID 151550 reaction equation
[Br:1][c:2]1[cH:3][c:4]([Cl:25])[c:5]([CH:8]([C:9]([C:10]([F:11])([F:12])[F:13])([OH:14])[c:15]2[cH:16][cH:17][c:18](=[O:23])[n:19]([CH2:21][CH3:22])[cH:20]2)[CH3:24])[cH:6][cH:7]1.[CH3:26][O:27][c:28]1[cH:29][c:30]([B:38]([OH:39])[OH:40])[cH:31][cH:32][c:33]1[C:34](=[O:35])[O:36][CH3:37]>>[c:2]1(-[c:30]2[cH:29][c:28]([O:27][CH3:26])[c:33]([C:34](=[O:35])[O:36][CH3:37])[cH:32][cH:31]2)[cH:3][c:4]([Cl:25])[c:5]([CH:8]([C:9]([C:10]([F:11])([F:12])[F:13])([OH:14])[c:15]2[cH:16][cH:17][c:18](=[O:23])[n:19]([CH2:21][CH3:22])[cH:20]2)[CH3:24])[cH:6][cH:7]1

Participants

3

Reactant 2

HCID 177502563-Methoxy-4-(methoxycarbonyl)benzeneboronic acidHCID 574213235-[2-(4-Bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-ethyl-1H-pyridin-2-one

Product 1

HCID 667826903'-Chloro-4'-[2-(1-ethyl-6-oxo-1,6-dihydro-pyridin-3-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-3-methoxy-biphenyl-4-carboxylic acid methyl ester

Sources & evidence

ORD record
ord-e1f2e1bf72494430a24d3fa8c0e4127e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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