3-Amino-4-methylbenzamide → HCID 59479498, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-amino-4-methylbenzamide (75 mg, 0.5 mmol), 3,4-dimethoxyphenylboronic acid (91 mg, 0.5 mmol) and glyoxylic acid monohydrate (46 mg, 0.5 mmol) in acetonitrile (2.0 mL) and DMF (0.2 mL) was heated at 100° C. for 20 min in a microwave reactor. After removal of solvent, the crude was triturated with methylene chloride. The precipitate formed was collected by filtration and washed with methylene chloride to give 5A after drying. 1H NMR (400 MHz, Methanol-d4) δ ppm 3.79 (s, 3H) 3.81 (s, 3H) 5.15 (s, 1H) 6.91 (d, J=8.35 Hz, 1H) 6.95 (s, 1H) 7.05-7.14 (m, 4H); LC-MS 345 (M+H).

Provenance & Evidence