Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-Aminobenzamide → 2-(3-Carbamoylphenylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-Aminobenzamide | HCID 1645 | — |
| 반응물 | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| 반응물 | 2-(3-Carbamoylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59838034 | — |
| 반응물 | Boronic acid, [3-ethoxy-4-(1-methylethoxy)phenyl]- | HCID 59838044 | — |
| 생성물 | 2-(3-Carbamoylphenylamino)-2-(3-ethoxy-4-isopropoxyphenyl)acetic acid | HCID 59479447 | 80% |
반응 단계
11A was prepared in a procedure similar to that of 1A using 3-aminobenzamide, 3-ethoxy-4-isopropoxyphenylboronic acid and glyoxylic acid monohydrate. Yield: 80%. 1H NMR (400 MHz, CDCl3) δ ppm 1.16 (d, J=6.15 Hz, 6 H) 1.25 (t, J=7.03 Hz, 3H) 3.88-3.97 (m, 2H) 4.32-4.45 (m, 1H) 4.93 (s, 1H) 6.64-6.69 (m, 1H) 6.80 (d, J=8.35 Hz, 1H) 6.92 (dd, J=8.35, 2.20 Hz, 1H) 6.95-7.07 (m, 4H). LCMS: 373 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08222453B2 |
| 출처 데이터셋 | uspto-grants-2012_07 |
| ORD ID | ord-acc5fcdd7ecf42f6b6ab697459397ab9 |
| 출처 메모 | uspto-grants-2012_07 |