HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3,4-Dimethoxyphenylboronic acid → 2-(5-Carbamoyl-2-fluorophenylamino)-2-(3,4-dimethoxyphenyl)acetic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3,4-Dimethoxyphenylboronic acid | HCID 2734702 | — |
| Edukt | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Edukt | 3-Amino-4-fluorobenzamide | HCID 16782100 | — |
| Edukt | 2-(3-Carbamoylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59838034 | — |
| Produkt | 2-(5-Carbamoyl-2-fluorophenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59479471 | 55% |
Reaktionsschritte
19C was prepared in a procedure similar to that of 1A using 19B, 3,4-dimethoxyphenylboronic acid and glyoxylic acid monohydrate. Yield: 55%. 1H NMR (400 MHz, Methanol-d4) δ ppm 3.78 (s, 3H) 3.81 (s, 3H) 5.15 (s, 1H) 6.90 (d, J=7.91 Hz, 1H) 7.01-7.08 (m, 2H) 7.12 (d, J=1.76 Hz, 1H) 7.13-7.17 (m, 2H), LCMS: 349 (M+1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08222453B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-da457efa483f4f6faa4b34a9dd44e02a |
| Quellennotiz | uspto-grants-2012_07 |