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HRID1515515

反应详情

EQUATION

反应方程式

HRID 1515515 的结构方程式

REACTANTS

反应物

4
结构：NC(=O)c1cc(N)ccc1F
HCID2778899

5-amino-2-fluorobenzamide

C7H7FN2O

结构：O.O=CC(=O)O
HCID15620607

Oxoacetic acid--water (1/1)

C2H4O4

结构：COc1ccc(C(Nc2ccc(F)c(C(N)=O)c2)C(=O)O)cc1OC
HCID59479392

未命名化合物

结构：CCOc1cc(B(O)O)ccc1OC(C)C
HCID59838044

{3-Ethoxy-4-[(propan-2-yl)oxy]phenyl}boronic acid

C11H17BO4

PRODUCTS

生成物

1
结构：CCOc1cc(C(Nc2ccc(F)c(C(N)=O)c2)C(=O)O)ccc1OC(C)C
HCID59479509

未命名化合物

收率 55%

PROCEDURE

实验过程

21A was prepared in a procedure similar to that of 13A using 3-amino-6-fluorobenzamide, 3-ethoxy-4-isopropoxyphenylboronic acid and glyoxylic acid monohydrate. Yield: 55%. 1H NMR (400 MHz, Methanol-d4) δ ppm 1.28 (s, 3H) 1.29 (s, 3H) 1.37 (t, J=7.03 Hz, 3H) 4.05 (q, J=7.03 Hz, 2H) 4.46-4.55 (m, 1H) 5.00 (s, 1H) 6.78-6.84 (m, 1H) 6.90-6.99 (m, 2H) 7.02 (dd, J=8.35, 2.20 Hz, 1H) 7.07-7.12 (m, 2H), LCMS: 391 (M+1).