HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3,4-Dimethoxyphenylboronic acid → 2-(5-Carbamoyl-2,4-difluorophenylamino)-2-(3,4-dimethoxyphenyl)acetic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3,4-Dimethoxyphenylboronic acid | HCID 2734702 | — |
| Edukt | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Edukt | 5-Amino-2,4-difluorobenzamide | HCID 25658239 | — |
| Edukt | 2-(3-Carbamoyl-4-fluorophenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59479392 | — |
| Produkt | 2-(5-Carbamoyl-2,4-difluorophenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59479410 | 80% |
Reaktionsschritte
23A was prepared in a procedure similar to that of 13A using 3-amino-4,6-difluorobenzamide, 3,4-dimethoxyphenylboronic acid and glyoxylic acid monohydrate. Yield: 80%. 1H NMR (400 MHz, Methanol-d4) δ ppm 3.73-3.87 (m, 6H) 5.07 (s, 1H) 6.92 (t, J=7.69 Hz, 1H) 6.96-7.13 (m, 4H), LCMS: 367 (M+1).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08222453B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-aac2b33af5ec40a89882f778732b365d |
| Quellennotiz | uspto-grants-2012_07 |