HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic acid, monohydrate → 2-(5-Carbamoyl-2-fluorophenylamino)-2-(3-ethoxy-4-fluorophenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | 3-Amino-4-fluorobenzamide | HCID 16782100 | — |
| Reactant | 3-Ethoxy-4-fluorobenzeneboronic acid | HCID 44558174 | — |
| Reactant | 2-(3-Carbamoylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59838034 | — |
| Product | 2-(5-Carbamoyl-2-fluorophenylamino)-2-(3-ethoxy-4-fluorophenyl)acetic acid | HCID 59479530 | 50% |
Reaction Steps
29A was prepared in a procedure similar to that of 1A using 19B, 9B and glyoxylic acid monohydrate. Yield: 50%. 1H NMR (400 MHz, Methanol-d4) δ ppm 1.40 (t, J=7.03 Hz, 3H) 4.10 (q, J=7.03 Hz, 2H) 5.17 (s, 1H) 7.03-7.11 (m, 3 H) 7.13-7.17 (m, 1H) 7.24 (d, J=8.79 Hz, 1H) 7.28 (d, J=9.23 Hz, 1H), LCMS: 351 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222453B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-c889debdd5eb47edbe2aadd39aa1ea9f |
| Source note | uspto-grants-2012_07 |