HuagongsheHuagongshe Chemistry Print Report · For research reference only
Glyoxylic acid, monohydrate → 2-(1,3-Dioxoisoindolin-5-ylamino)-2-(4-fluoro-3-methoxyphenyl)acetic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Glyoxylic acid, monohydrate | HCID 15620607 | — |
| Reactant | (4-Fluoro-3-methoxyphenyl)boronic acid | HCID 44558185 | — |
| Reactant | 2-(3-Carbamoylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid | HCID 59838034 | — |
| Reactant | 5-Iminoisoindoline-1,3-dione | HCID 68106733 | — |
| Product | 2-(1,3-Dioxoisoindolin-5-ylamino)-2-(4-fluoro-3-methoxyphenyl)acetic acid | HCID 59479522 | 17% |
Reaction Steps
43A was prepared in a procedure similar to that of 1A using 5-iminoisoindoline-1,3-dione, 7C and glyoxylic acid monohydrate. Yield: 17%. 1H NMR (400 MHz, Methanol-d4) δ ppm 3.87 (s, 3H) 5.21 (s, 1H) 6.90 (dd, J=8.35, 2.20 Hz, 1H) 6.99 (d, J=1.76 Hz, 1H) 7.06-7.12 (m, 2H) 7.28 (d, J=8.79 Hz, 1H) 7.51 (d, J=8.35 Hz, 1H), LCMS: 345 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222453B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-46763461ceaa4ecfa8497aaf11c3d181 |
| Source note | uspto-grants-2012_07 |