2-(3-Carbamoylphenylamino)-2-(4-fluoro-3-methoxyphenyl)acetic acid → 3-((R)-2-((R)-2-(5-(3,3-Dimethylureido)-2-(isopropylsulfonyl)phenyl)pyrrolidin-1-yl)-1-(4-fluoro-3-methoxyphenyl)-2-oxoethylamino)benzamide

Participants

Role	Name	HCID	Charge
Reactant	2-(3-Carbamoylphenylamino)-2-(4-fluoro-3-methoxyphenyl)acetic acid	HCID 59479411	—
Reactant	(R)-3-(4-(isopropylsulfonyl)-3-(pyrrolidin-2-yl)phenyl)-1,1-dimethylurea hydrochloride	HCID 68439178	—
Product	3-((R)-2-((R)-2-(5-(3,3-Dimethylureido)-2-(isopropylsulfonyl)phenyl)pyrrolidin-1-yl)-1-(4-fluoro-3-methoxyphenyl)-2-oxoethylamino)benzamide	HCID 59479467	—

Reaction Steps

Example 59 was prepared according to the general coupling condition using 7D and 31A. 1H NMR (400 MHz, Methanol-d4) δ ppm 1.15 (d, J=6.57 Hz, 3 H) 1.40 (d, J=6.82 Hz, 3H) 1.64-1.80 (m, 1H) 1.92-2.20 (m, 2H) 2.39-2.57 (m, 1H) 2.97 (s, 6H) 3.62-3.76 (m, 4H) 3.81-3.95 (m, 1H) 4.06-4.18 (m, 1H) 5.38 (s, 1H) 5.63 (dd, J=8.08, 5.05 Hz, 1H) 6.78-6.89 (m, 2H) 6.93-7.08 (m, 3H) 7.09-7.22 (m, 3H) 7.25 (dd, J=8.72, 2.15 Hz, 1H) 7.69 (d, J=8.84 Hz, 1H), LC-MS 640 (M+H).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08222453B2
Source dataset	uspto-grants-2012_07
ORD ID	ord-dc5f919613ae40fd8374c8ebf1d02e85
Source note	uspto-grants-2012_07