HCID 131729845, compound → HCID 59479519, compound

Participants

Reaction Steps

To 76G (2.9 g) in methanol (60 mL) was added 10% Pd/C (990 mg). The mixture was hydrogenated with a hydrogen balloon for 2.0 h. The Pd/C was removed by filtration and the filtrate was concentrated to afford 76I (2.54 g, 95% yield). 1H NMR (400 MHz, DMSO-d6, 100° C.) δ ppm 0.83-0.93 (m, 5H) 0.95-1.04 (m, 2H) 1.13-1.24 (m, 11H) 2.02-2.07 (m, 1H) 2.09-2.16 (m, 1H) 2.73-2.79 (m, 1H) 3.48-3.56 (m, 1H) 3.63-3.74 (m, 4H) 5.79 (d, J=7.70 Hz, 1H) 6.48-6.54 (m, 2H) 7.40 (d, J=8.79 Hz, 1H), LC-MS 439 (M+H).

Provenance & Evidence