2-(5-Carbamoyl-2-fluorophenylamino)-2-(4-fluoro-3-methoxyphenyl)acetic acid → HCID 24880759, compound

Participants

Reaction Steps

Example 80 was prepared according to the general coupling condition using 27A and 76O. 1H NMR (400 MHz, Methanol-d4) δ ppm 0.84 (t, J=7.20 Hz, 3H) 0.95-1.17 (m, 3H) 1.33-1.47 (m, 1H) 2.20-2.35 (m, 1H) 2.41 (d, J=6.82 Hz, 1H) 2.91-3.06 (m, 6H) 3.16-3.27 (m, 1H) 3.50-3.64 (m, 2H) 3.69 (s, 3H) 3.71-3.79 (m, 1H) 3.81-3.97 (m, 1H) 4.13-4.28 (m, 1H) 5.46 (s, 1H) 6.26 (d, J=8.34 Hz, 1H) 6.66 (d, J=2.27 Hz, 1H) 6.90-7.09 (m, 4H) 7.10-7.17 (m, 1H) 7.30 (dd, J=8.34, 2.02 Hz, 1H) 7.38-7.45 (m, 1H) 7.66 (d, J=8.84 Hz, 1H), LC-MS 728 (M+H).

Provenance & Evidence