2-(5-Carbamoyl-2-fluorophenylamino)-2-(4-fluoro-3-methoxyphenyl)acetic acid → HCID 24880695, compound

Participants

Reaction Steps

Example 87 was prepared according to the general coupling condition using 27A and 85J. 1H NMR (400 MHz, Methanol-d4) δ ppm 1.00-1.08 (m, 2H) 1.13 (m, 1H) 1.36-1.43 (m, 1H) 1.73 (m, 1H) 2.02-2.14 (m, 2H) 2.52 (m, 1H) 3.22-3.29 (m, 1H) 3.71 (s, 6H) 4.16 (ddd, J=10.22, 6.81, 6.70 Hz, 1H) 5.46 (s, 1H) 5.88 (dd, J=7.91, 5.27 Hz, 1H) 6.98-7.06 (m, 4H) 7.08-7.15 (m, 3H) 7.32 (dd, J=8.35, 1.76 Hz, 1H) 7.68 (d, J=9.23 Hz, 1H) 9.44 (s, 1H), LC-MS 643 (M+H).

Provenance & Evidence