HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 3-Amino-5-fluorobenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 3-Fluoro-5-nitrobenzoic acid | HCID 2759047 | — |
| Reactant | 3-Amino-5-methylbenzamide | HCID 53988441 | — |
| Product | 3-Amino-5-fluorobenzamide | HCID 46835333 | — |
Reaction Steps
Using a procedure analogous to that described for preparation of 89C, 3-fluoro-5-nitrobenzoic acid was converted to an acid chloride, reacted with aqueous ammonia, and hydrogenated to give 91A. 1H NMR (400 MHz, CD3OD) δ ppm 6.55 (dt, J=10.99, 2.20 Hz, 1H) 6.79 (m, 1H) 6.95 (t, J=1.54 Hz, 1H); LC/MS 155 (M+H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222453B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-32a418406be54399ab9d44aa50ebdea5 |
| Source note | uspto-grants-2012_07 |