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HRID1515559

反应详情

EQUATION

反应方程式

HRID 1515559 的结构方程式

REACTANTS

反应物

4
结构：COc1ccc(B(O)O)cc1OC
HCID2734702

3,4-Dimethoxyphenylboronic acid

C8H11BO4

结构：O.O=CC(=O)O
HCID15620607

Oxoacetic acid--water (1/1)

C2H4O4

结构：NC(=O)c1cc(N)cc(F)c1
HCID46835333

3-Amino-5-fluorobenzamide

C7H7FN2O

结构：COc1ccc(C(Nc2cc(C)cc(C(N)=O)c2)C(=O)O)cc1OC
HCID59479497

2-(3-Carbamoyl-5-methylphenylamino)-2-(3,4-dimethoxyphenyl)acetic acid

C18H20N2O5

PRODUCTS

生成物

1
结构：COc1ccc(C(Nc2cc(F)cc(C(N)=O)c2)C(=O)O)cc1OC
HCID59479507

未命名化合物

PROCEDURE

实验过程

Using a procedure analogous to that described for the preparation of 89D, 91A was reacted with 3,4-dimethoxyphenylboronic acid and glyoxylic acid monohydrate to give 91B. 1H NMR (400 MHz, CD3OD) δ ppm 3.81 (s, 3H) 3.82 (s, 3H) 5.06 (s, 1H) 6.49 (d, J=11.43 Hz, 1H) 6.79 (d, J=9.23 Hz, 1H) 6.93 (d, J=8.35 Hz, 1H) 6.97 (s, 1H) 7.04-7.10 (m, 1H) 7.12 (s, 1H); LC/MS 349 (M+H).