化工社化工社 化学情報印刷レポート · 研究参考用
5-Azidonicotinamide → 3-Pyridinecarboxamide, 5-amino-
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 5-Azidonicotinamide | HCID 59479456 | — |
| 反応物 | HCID 178418361 | HCID 178418361 | — |
| 触媒 | Palladium | HCID 23938 | — |
| 溶媒 | Methanol | HCID 887 | — |
| 生成物 | 3-Pyridinecarboxamide, 5-amino- | HCID 173747 | 36% |
反応手順
97A was hydrogenated in MeOH with 10% Pd/C (20 mg) with a hydrogen balloon for 0.5 h. The Pd/C was removed by filtration. The filtrate was concentrated to give 97B (25 mg, 36% yield for two steps). 1H NMR (400 MHz, Methanol-d4) δ ppm 7.43-7.49 (m, 1H) 8.07 (d, J=2.64 Hz, 1H) 8.22 (d, J=1.76 Hz, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08222453B2 |
| 出典データセット | uspto-grants-2012_07 |
| ORD ID | ord-4735485e3f974634a7ae9994d18f4540 |
| 出典メモ | uspto-grants-2012_07 |