反应详情

A mixture of 1-benzenesulfonyl-2-[1-(4-methanesulfonyl-phenyl)-3-methyl-but-1-enyl]-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid methyl ester (800 mg, 1.48 mmol) in ethanol (4 mL) and an aqueous sodium hydroxide solution (10%, 1.5 mL) was heated at 100° C. for 1 h. The mixture was acidified to pH 4-5 with a 2N aqueous hydrochloric acid solution, diluted with dichloromethane (150 mL), washed with water, dried over anhydrous sodium sulfate and then concentrated in vacuo to afford 2-[1-(4-methanesulfonyl-phenyl)-3-methyl-but-1-enyl]-1H-pyrrolo[2,3-b]pyridin-5-carboxylic acid (540 mg, 95%) as a light yellow solid which was used without further purification: LC/MS m/e calcd for C20H20N2O4S [M+H]+ 385.46, observed 385.3.

1. washwashed with water
2. dry with materialdried over anhydrous sodium sulfate
3. concentrationconcentrated in vacuo