Potassium Permanganate → HCID 67228387, compound

Participants

Reaction Steps

To a stirred solution of 1-(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-1-(4-methaneylsulfinyl-phenyl)-ethanol (5.1 g, 10 mmol) in methanol (150 mL) and water (30 mL) at room temperature was added potassium permanganate (948 mg, 6 mmol). The mixture was stirred at room temperature for 2 h, diluted with ethyl acetate (150 mL), washed with brine, dried over anhydrous sodium sulfate and concentrated in vacuo to afford 1-(1-benzenesulfonyl-5-fluoro-1H-pyrrolo[2,3-b]pyridin-2-yl)-2-cyclopentyl-1-(4-methanesulfonyl-phenyl)-ethanol (5.1 g, 94%) as a light yellow solid: LC/MS m/e calcd for C27H27FN2O5S2 [M+H]+ 543.65, observed 542.9.

Provenance & Evidence