HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → 7-Hydroxy-hept-2-enoic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | 2-Hydroxytetrahydropyran | HCID 136505 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 7-Hydroxy-hept-2-enoic acid ethyl ester | HCID 71331342 | — |
Reaction Steps
A solution of 2-hydroxytetrahydropyran (59.2 g, 0.58 mol) and triphenyl-λ5-phosphanylidene)-acetic acid ethyl ester (201.3 g, 0.58 mol) in tetrahydrofuran (1.2 L) was heated at reflux for 14 h. The mixture was cooled to room temperature to afford 7-hydroxy-hept-2-enoic acid ethyl ester in tetrahydrofuran and was then used directly in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08222416B2 |
| Source dataset | uspto-grants-2012_07 |
| ORD ID | ord-fafbc42bb7a64f7ab1388f63b65eef0c |
| Source note | uspto-grants-2012_07 |