反应详情

To a solution of 2-(tetrahydro-pyran-2-yl)-ethanol (53.5 g, 0.41 mol) in dichloromethane (1 L) was added pyridinium chlorochromate (176.8 g, 0.82 mol) in small portions at room temperature. The dark suspension was stirred for 3 h. The mixture was filtered through a short pad of silica gel. The filtrate was concentrated in vacuo and the residue was diluted with n-hexane (400 mL). The mixture was filtered through a short pad of silica gel and the filtrate was concentrated in vacuo to afford (tetrahydro-pyran-2-yl)-acetaldehyde (38 g) as a colorless oil.

1. filtrationThe mixture was filtered through a short pad of silica gel
2. concentrationThe filtrate was concentrated in vacuo
3. additionthe residue was diluted with n-hexane (400 mL)
4. filtrationThe mixture was filtered through a short pad of silica gel
5. concentrationthe filtrate was concentrated in vacuo