HuagongsheHuagongshe Chemistry Print Report · For research reference only
(5-[(1,1-Dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate → {5-[(1,1-Dimethylethyl)thio]-4-oxo-1,4-dihydro-2-pyridinyl}methyl acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (5-[(1,1-Dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate | HCID 68598711 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| Product | {5-[(1,1-Dimethylethyl)thio]-4-oxo-1,4-dihydro-2-pyridinyl}methyl acetate | HCID 67526579 | 100.6% |
Reaction Steps
A solution of (5-[(1,1-dimethylethyl)thio]-4-[(phenylmethyl)oxy]-2-pyridinyl}methyl acetate (6 g) in 1,4-dioxane/water (100 ml/50 ml) was hydrogenated at atmospheric pressure with 10% palladium on charcol (7 g) overnight. Filtration and evaporation afforded a white solid (4.46 g, 95%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732460B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-50588ac79e3c4fe893f88290c98fec15 |
| Source note | uspto-grants-2010_06 |