反应详情

A mixture of 5-nitroanthranilic acid (2 g, 14.6 mmol) and formamide (2.9 ml, 72 mmol) is irradiated at 150 C in a microwave (power: 60 W) until TLC shows completion of reaction (20 minutes). After cooling, the reaction mixture is rinsed with ethyl acetate and evaporated under reduced pressure. The crude is purified by flash chromatography (silica gel; ethyl acetate/hexanes) to give the above product.

1. customis irradiated at 150 C in a microwave (power: 60 W) until TLC
2. customcompletion of reaction (20 minutes)
3. temperatureAfter cooling
4. washthe reaction mixture is rinsed with ethyl acetate
5. customevaporated under reduced pressure
6. customThe crude is purified by flash chromatography (silica gel; ethyl acetate/hexanes)
7. customto give the above product