反应详情

温度

90 °C

A mixture of 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (1.0 g, 3 mmol), hydrazine (3.09 g, 62 mmol) and ethanol (1 mL) was heated at 90° C. for 5 h. The mixture was cooled and concentrated to give a white residue that was triturated with chloroform and filtered. The filtrate was concentrated to afford the title compound (743 mg, 49%) as a white solid. MS: m/e=325.4 [M+H]+.

1. temperatureThe mixture was cooled
2. concentrationconcentrated
3. customto give a white residue that
4. customwas triturated with chloroform
5. filtrationfiltered
6. concentrationThe filtrate was concentrated