1-Aminopiperidine → HCID 49800976, compound

HRID 1516195Notes

Reaction equation

HRID 1516195 reaction equation
[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=1.[NH2:24][N:25]1[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]1>>[CH3:1][C:2]1[O:6][N:5]=[C:4]([C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:3]=1[CH2:13][O:14][C:15]1[CH:23]=[CH:22][C:18]([C:19]([NH:24][N:25]2[CH2:30][CH2:29][CH2:28][CH2:27][CH2:26]2)=[O:21])=[CH:17][N:16]=1

Participants

3

Reactant 2

HCID 166581-AminopiperidineHCID 665992136-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

Product 1

HCID 49800976HCID 49800976, compoundYield 21%

Procedure

As described for example 2b, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (100 mg, 0.32 mmol) was converted, using N-aminopiperidine instead of N-aminomorpholine to the title compound (27 mg, 21%) which was obtained as a white solid. MS: m/e=393.2 [M+H]+.

Sources & evidence

ORD record
ord-4e64601461414c8aa1a51972673ffc5f
Source dataset
uspto-grants-2012_07
Patent number
US08227461B2

Reaction notes

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