HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1516218Erstellt: 25. Oktober 2026
tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate → {5-[2-(1-Cyano-cyclobutyl)-pyridin-4-yl]-4-methyl-thiazol-2-yl}-carbamic acid tert-butyl ester
https://huagongshe.com/reaction/1516218
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | tert-butyl N-(4-methyl-1,3-thiazol-2-yl)carbamate | HCID 45117839 | — |
| Edukt | 1-(4-Bromopyridin-2-yl)cyclobutane-1-carbonitrile | HCID 57417094 | — |
| Produkt | {5-[2-(1-Cyano-cyclobutyl)-pyridin-4-yl]-4-methyl-thiazol-2-yl}-carbamic acid tert-butyl ester | HCID 59293719 | — |
Reaktionsschritte
The title compound is prepared in analogy to the procedure described in Step 1.3, but using 1-(4-bromo-pyridin-2-yl)-cyclobutanecarbonitrile (Step 19.3) and (4-methyl-thiazol-2-yl)-carbamic acid tert-butyl ester (Step 18.4). The reaction mixture is stirred for 3 h at 100° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08227462B2 |
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| Quelldatensatz | uspto-grants-2012_07 |
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| ORD ID | ord-99d927e6c98b4d5088498ff2924954e4 |
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| Quellennotiz | uspto-grants-2012_07 |
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