Chlorotrimethylsilane → HCID 59293690, compound

HRID 1516242Notes

Reaction equation

HRID 1516242 reaction equation
C[Si](Cl)(C)C.[CH3:6][C:7]1[N:8]=[C:9]([NH:22]C(=O)C)[S:10][C:11]=1[C:12]1[CH:13]=[N:14][CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1>C(O)C>[CH3:6][C:7]1[N:8]=[C:9]([NH2:22])[S:10][C:11]=1[C:12]1[CH:13]=[N:14][CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=1

Participants

4

Reactant 2

HCID 6397ChlorotrimethylsilaneHCID 59293758HCID 59293758, compound

Product 1

HCID 59293690HCID 59293690, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Trimethylsilyl chloride (0.3 ml) is added to N-[4-methyl-5-(5-trifluoromethyl-pyridin-3-yl)-thiazol-2-yl]-acetamide (44 mg) in ethanol (2 ml) at room temperature and the mixture is stirred at room temperature for 4.5 hours. The reaction is then heated at 50° C. for 18 hours, cooled, evaporated and the title compound is obtained by filtration after trituration with diethyl ether.

Workup

  1. temperatureThe reaction is then heated at 50° C. for 18 hours
  2. temperaturecooled
  3. customevaporated

Sources & evidence

ORD record
ord-723dba8d3bbe404aa6d619049479223d
Source dataset
uspto-grants-2012_07
Patent number
US08227462B2

Reaction notes

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