反应详情

The ester of Step 1 (1.63 g, 5.4 mmol) was added to a solution of potassium hydroxide (330 mg, 5.9 mmol) in methanol (20 mL) and the reaction mixture stirred at room temperature for 18 hours. The reaction mixture was concentrated in vacuo and the crude product dissolved in water and washed with ether. The aqueous phase was acidified with 2M hydrochloric acid and extracted into dichloromethane (3×100 mL). The organics were combined, dried over magnesium sulphate and concentrated in vacuo to yield the title product.

1. concentrationThe reaction mixture was concentrated in vacuo
2. dissolutionthe crude product dissolved in water
3. washwashed with ether
4. extractionextracted into dichloromethane (3×100 mL)
5. dry with materialdried over magnesium sulphate
6. concentrationconcentrated in vacuo