Methyl Isocyanate → HCID 67473768, compound

Participants

Reaction Steps

To a solution of 4-fluoro-N-[(1S,2S)-2-hydroxy-6-[4-(oxetan-3-yl)piperazin-1-yl]indan-1-yl]benzamide (220 mg, 0.535 mmol) in tetrahydrofuran (3.0 mL) add 4-pyrrolidinopyridine (16 mg, 0.107 mmol) and seal in a pressure vial. Add methyl isocyanate (97 μL, 1.60 mmol) by syringe to the mixture and stir at 60° C. overnight. Cool the resulting suspension in an ice bath, collect the white solid by filtration, and dry in a vacuum oven at 40° C. for 3 hr. to obtain the title compound (200 mg, 80%). LC-ES/MS m/z 469 [M+H]+.

Provenance & Evidence