HCID 67238193, compound → HCID 178480677, compound

HRID 1516363Notes

Reaction equation

HRID 1516363 reaction equation
C(OC([N:6]1[C:10]([NH:11][C:12](=[O:26])[C:13]2[CH:18]=[CH:17][C:16]([N:19]3[CH2:24][CH2:23][N:22]([CH3:25])[CH2:21][CH2:20]3)=[CH:15][CH:14]=2)=[C:9]2[CH2:27][N:28]([C:32](=[O:42])[NH:33][C:34]3[C:39]([Cl:40])=[CH:38][CH:37]=[CH:36][C:35]=3[Cl:41])[C:29]([CH3:31])([CH3:30])[C:8]2=[N:7]1)=O)C>CO>[Cl:40][C:39]1[CH:38]=[CH:37][CH:36]=[C:35]([Cl:41])[C:34]=1[NH:33][C:32]([N:28]1[CH2:27][C:9]2[C:8](=[N:7][NH:6][C:10]=2[NH:11][C:12](=[O:26])[C:13]2[CH:14]=[CH:15][C:16]([N:19]3[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]3)=[CH:17][CH:18]=2)[C:29]1([CH3:31])[CH3:30])=[O:42]

Participants

3

Reactant 1

HCID 67238193HCID 67238193, compound

Product 1

HCID 178480677HCID 178480677, compoundYield 76%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(2,6-Dichloro-phenylcarbamoyl)-6,6-dimethyl-3-[4-(4-methyl-piperazin-1-yl)-benzoylamino]-5,6-dihydro-4H-pyrrolo[3,4-c]pyrazole-2-carboxylic acid ethyl ester (0.6 g, 0.97 mmol) was dissolved in methanol (20 mL), treated with TEA (0.67 mL, 4.85 mmol, 5 eq) and stirred overnight at room temperature. After evaporation of the solvent, the solid was treated with diethyl ether and filtered to afford 0.28 g (yield 76%) of the title compound.

Workup

  1. customAfter evaporation of the solvent
  2. additionthe solid was treated with diethyl ether
  3. filtrationfiltered

Sources & evidence

ORD record
ord-51275b76c3e345339b693a9667d4379b
Source dataset
uspto-grants-2012_07
Patent number
US08227472B2

Reaction notes

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