HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
5-Bromo-N-((1SR,2RS)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide → 5-Bromo-N-((1S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 5-Bromo-N-((1SR,2RS)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide | HCID 58192591 | — |
| Lösungsmittel | Isopropanol heptane | HCID 21225753 | — |
| Produkt | 5-Bromo-N-((1S,2R)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide | HCID 69812295 | 47,7% |
Reaktionsschritte
5-Bromo-N-((1SR,2RS)-2-hydroxy-cyclohexyl)-6-(2,2,2-trifluoro-ethoxy)-nicotinamide (91.3 g, 0.23 mol) was submitted to preparative HPLC on ChiralPak AD® (250×110 mm column) using n-heptane/isopropanol 85/15 as mobile phase. Baseline separation was achieved and the title compound (43.6 g) was isolated as colorless solid from the first peak; MS (ISP) 395.2, 397.2 (M−H); ORD (589 nM, 20° C., CHCl3) −21.6°.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08227491B2 |
| Quelldatensatz | uspto-grants-2012_07 |
| ORD ID | ord-ace58693f81548459d536001f485cad8 |
| Quellennotiz | uspto-grants-2012_07 |