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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1516388Generated: November 4, 2026

N2,N2,3-trimethylpyridine-2,5-diamine → N-[6-(Dimethylamino)-5-methylpyridin-3-yl]-5-fluoro-1-(pyridin-4-ylmethyl)-1H-indole-2-carboxamide

https://huagongshe.com/reaction/1516388

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN2,N2,3-trimethylpyridine-2,5-diamineHCID 25094153—
Reactant5-Fluoro-1-(pyridin-4-ylmethyl)-1H-indole-2-carboxylic acidHCID 57431534—
ProductN-[6-(Dimethylamino)-5-methylpyridin-3-yl]-5-fluoro-1-(pyridin-4-ylmethyl)-1H-indole-2-carboxamideHCID 68932967—

Reaction Steps

Compound No. 19 is prepared from 5-fluoro-1-(pyridin-4-ylmethyl)-1H-indole-2-carboxylic acid, synthesized in stage 5.1, and 3-amino-5-methyl-6-(dimethylamino)pyridine (GB 870 027) according to a process similar to that described in example No. 3.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08227489B2
Source datasetuspto-grants-2012_07
ORD IDord-fbbf627ac6ed44bdb6d592a8ab5bc7c9
Source noteuspto-grants-2012_07